Approximately 50 million people suffer from sepsis every year, with approximately 13,7 million succumbing to the illness. Nevertheless, sepsis is practically unknown to the general public. The Global Sepsis Alliance (GSA), established in 2010, is a non-profit charitable organisation established with the mission of providing global leadership to reduce the worldwide burden of sepsis. At this stage in the fight against sepsis, professional leadership and greater support for the front-line efforts of our Regional Alliances are essential. From experience, we know that our ultimate success will be highly dependent on efforts to educate government officials, healthcare workers, and the general public.